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Novel Pt(II) and Pd(II) complexes with polyamine analogues: Synthesis and vibrational analysis.

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Author

Summary, in English

A vibrational spectroscopy study (infrared and Raman) is reported for the biogenic polyamine analogues norspermidine (NSpd), N(1),N(11)-bis(ethyl)norspermine (BENSpm) and N(1)-cyclo-propylmethyl-N(11)-ethylnorspermine (CPENSpm), as well as for their newly synthesised Pt(II) and Pd(II) complexes. Attending to the potential antineoplastic properties of this kind of systems, their full conformational characterization is essential for understanding the molecular basis of their cytotoxic activity and the mechanisms through which they are transported into the cell. The all-trans geometry was found to be favoured for all the alkylated polyamines, in their totally protonated state, while their polynuclear complexes presented a stable geometry very similar to that previously obtained for the analogous chelates with spermidine (M(3)Spd(2)) and spermine (M(2)Spm), comprising two or three cisplatin-like (MCl(2)NH(2)) moieties.

Department/s

Publishing year

2012

Language

English

Pages

1-7

Publication/Series

Journal of Inorganic Biochemistry

Volume

108

Issue

March

Document type

Journal article

Publisher

Elsevier

Topic

  • Pharmacology and Toxicology

Keywords

  • Modified polyamines
  • Pt(II) / Pd(II) complexes
  • Raman spectroscopy
  • Infrared spectroscopy
  • Anticancer

Status

Published

Research group

  • Biogenic Amines

ISBN/ISSN/Other

  • ISSN: 1873-3344