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Alpha-ketoglutarate stabilizes redox homeostasis and improves arterial elasticity in aged mice

På svenska

Author

  • T. Niemiec
  • J. Sikorska
  • A. Harrison
  • M. Szmidt
  • E. Sawosz
  • E. Wirth-Dzieciolowska
  • J. Wilczak
  • Stefan Pierzynowski

Summary, in English

The objective of this study was to evaluate the effect of alpha-ketoglutarate on redox state parameters and arterial elasticity in elderly mice. Mice in the control group were fed with standard diet, while the experimental animals received the diet supplemented either with calcium (Ca-AKG) or sodium salt of alpha-ketoglutarate (Na-AKG). The experimental animals were divided into 4 groups with 10 individuals in each: control I (12 months old), control II (2 months old), experimental group I fed with Ca-AKG (12 months old) and experimental group II fed with Na-AKG (12 months old). Mice treated with Ca-AKG as well as the control II animals demonstrated significantly higher level of total antioxidant status (TAS), comparing to the control I animals and those treated with Ca-AKG. Thiobarbituric acid reactive substances (TBARS) level in blood plasma was found significantly lower in young and Ca-AKG treated mice. TBARS liver concentration was significantly different in each examined group. The study also demonstrates the decrease in TBARS level in Ca-AKG treated animals. Treatment with Na-AKG significantly increased glutathione peroxidase activity and decreased the activity of superoxide dismutase. The presented results suggest that Ca-AKG protects the organism against the free radicals related elderly processes. The study presents also the effect of Ca-AKG treatment on arterial elastic characteristics in elderly mice. The beneficial effect of Ca-AKG on ageing organisms was confirmed via redox state stabilization and blood vessel elasticity improvement.

Department/s

Publishing year

2011

Language

English

Pages

37-43

Publication/Series

Journal of Physiology and Pharmacology

Volume

62

Issue

1

Document type

Journal article

Publisher

Polish Physiological Society

Topic

  • Zoology

Keywords

  • alpha-ketoglutarate
  • aorta elasticity
  • glutathione peroxidase
  • redox
  • reactive oxygen species
  • total antioxidant status
  • superoxide
  • dismutase
  • thiobarbituric acid reactive substances

Status

Published

ISBN/ISSN/Other

  • ISSN: 0867-5910