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New directions of miniaturization within the proteomics research area

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Author

Summary, in English

An overview of the current trends within protein expression profiling is given where multidimensional separation of both gel- and liquid-phase techniques linked to mass spectrometry is viewed as a major route in the global proteome mapping. A clear trend in these biochemical developments is the effort to sequence and identify low-abundant protein expressions where assay miniaturization and integrated sample processing plays a central role. Two areas of miniaturization within the proteomics field are addressed: (i) sample cleanup and enrichment, and (ii) silicon microstructure developments for protein chip microarrays.

Publishing year

2003

Language

English

Pages

3521-3532

Publication/Series

Electrophoresis

Volume

24

Issue

21

Document type

Journal article review

Publisher

John Wiley & Sons Inc.

Topic

  • Medical Engineering
  • Analytical Chemistry

Keywords

  • proteomics
  • miniaturization
  • protein expression profiling
  • review

Status

Published

ISBN/ISSN/Other

  • ISSN: 0173-0835