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Additional transplantation of ex vivo generated megakaryocytic cells after high-dose chemotherapy

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Author

  • Stefan Scheding
  • Markus Bergmannn
  • Gisa Rathke
  • Wichard Vogel
  • Wolfram Brugger
  • Lothar Kanz

Summary, in English

The additional transplantation of ex vivo generated hematopoietic (post)-progenitor cells represents a possible approach to ameliorate high-dose chemotherapy induced cytopenia. We investigated the feasibility of the large-scale expansion and transplantation of autologous megakaryocytic cells in four patients with advanced solid tumors. Up to 1,460x10(6) ex vivo generated cells were administered without adverse effects but no clear cut effect on platelet recovery was observed.

Publishing year

2004

Language

English

Pages

630-631

Publication/Series

Haematologica

Volume

89

Issue

5

Document type

Journal article (letter)

Publisher

Ferrata Storti Foundation

Topic

  • Hematology

Status

Published

ISBN/ISSN/Other

  • ISSN: 1592-8721