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COMPRENDO: Focus and approach.

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Author

  • U Schulte-Oehlmann
  • T Albanis
  • A Allera
  • J Bachmann
  • Pia Berntsson
  • N Beresford
  • DC Carnevali
  • F Ciceri
  • T Dagnac
  • J Falandysz
  • S Galassi
  • D Hala
  • G Janer
  • R Jeannot
  • S Jobling
  • I King
  • D Klingmüller
  • W Kloas
  • KO Kusk
  • R Levada
  • S Lo
  • I Lutz
  • J Oehlmann
  • Stina Oredsson
  • C Porte
  • M Rand-Weaver
  • V Sakkas
  • M Sugni
  • C Tyler
  • R van Aerle
  • C van Ballegoy
  • L Wollenberger
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Summary, in English

Tens of thousands of man-made chemicals are in regular use and discharged into the environment. Many of them are known to interfere with the hormonal systems in humans and wildlife. Given the complexity of endocrine systems, there are many ways in which endocrine-disrupting chemicals (EDCs) can affect the body's signaling system, and this makes unraveling the mechanisms of action of these chemicals difficult. A major concern is that some of these EDCs appear to be biologically active at extremely low concentrations. There is growing evidence to indicate that the guiding principle of traditional toxicology that "the dose makes the poison" may not always be the case because some EDCs do not induce the classical dose-response relationships. The European Union project COMPRENDO (Comparative Research on Endocrine Disrupters--Phylogenetic Approach and Common Principles focussing on Androgenic/Antiandrogenic Compounds) therefore aims to develop an understanding of potential health problems posed by androgenic and antiandrogenic compounds (AACs) to wildlife and humans by focusing on the commonalities and differences in responses to AACs across the animal kingdom (from invertebrates to vertebrates) .

Publishing year

2006

Language

English

Pages

98-100

Publication/Series

Environmental Health Perspectives

Volume

114

Issue

Supplement 1

Document type

Journal article

Publisher

National Institute of Environmental Health Sciences

Topic

  • Environmental Health and Occupational Health

Keywords

  • phylogenetic approach
  • wildlife exposure.
  • molecular screening
  • environmental health
  • antiandrogens
  • androgens
  • endocrine disruptor

Status

Published

ISBN/ISSN/Other

  • ISSN: 1552-9924