Understanding Drug Uptake and Binding within Targeted Disease Micro-Environments in Patients: A New Tool for Translational Medicine

Summary, in English

For many common global diseases, such as cancer, diabetes, neurodegenerative and cardiovascular diseases there is an unmet need for diagnosing early indications of disease that could enable medical intervention and early treatment. For example, cigarette smoking causes a variety of deadly diseases including lung cancer, hypertension, chronic obstructive pulmonary disease (COPD) and cardiovascular diseases. The treatment of these diseases will require detailed knowledge of targeted pathways involved in disease pathogenesis but also the mode of drug actions at the biological location on these targets. New methods, such as matrix assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) are ready to provide insights into the fate (destinations and distributions) of administered drugs. Translational medicine is a new area of research where expert from different disciplines involved in basic science and clinical disciplines meet and join forces. The ultimate goal is to identify bridging comprehension that forms a knowledge base that can be used by society to develop a better treatment and medicine for patients.

• Author: György Marko-Varga; Ákos Végvári; Melinda Rezeli; Kaiu Prikk; Peeter Ross; Magnus Dahlbäck; Goutham Edula; Ruth Sepper; Thomas Fehniger
• Department/s: Department of Biomedical Engineering
• Publishing year: 2012
• Language: English
• Publication/Series: Clinical and Translational Medicine
• Volume: 1
• Links: http://dx.doi.org/10.1186/2001-1326-1-8
• Document type: Journal article
• Publisher: Wiley
• Topic: Clinical Medicine
• Status: Published
• ISBN/ISSN/Other: ISSN: 2001-1326