Genetic, environmental and life-style effects on androgen receptor function
Author
Summary, in English
We found that the CAG variant with the median length had the highest AR activity, shown both in cell lines and prostate tissue, and as highest PSA concentration in younger and older men. The unprejudiced statistical analysis gave a better picture of the relationship between CAG number and reproductive outcomes, demonstrating a CAG-dependent effect on hormone levels. The CAG repeat also had a cell line- and dose-dependent modulating effect of POPs on AR activity and was negatively associated with semen volume in smoking men.
To conclude, the median AR CAG number had the highest activity in vivo and in vitro. This pattern consisted even in the presence of POPs, indicating a stronger resistance for the median CAG length to these compounds compared to less common variants. The CAG number was also associated with reproductive hormone regulation and might modify the susceptibility of current cigarette smoking on semen volume in young men.
Publishing year
2012
Language
English
Publication/Series
Lund University Faculty of Medicine Doctoral Dissertation Series
Volume
2012:87
Full text
Document type
Dissertation
Publisher
Lund University
Topic
- Obstetrics, Gynecology and Reproductive Medicine
Keywords
- reproductive function
- smoking
- 4'.4-DDE
- persistent organic pollutants
- prostate cancer
- Androgen receptor
- prostate specific antigen
- CAG polymorphism
- TCDD
- aryl hydrocarbon receptor
- CB-153
Status
Published
Research group
- Molecular genetic reproductive medicine, Malmö
Supervisor
- Yvonne Giwercman
- Lars Rylander
- Pirkko Härkönen
ISBN/ISSN/Other
- ISSN: 1652-8220
- ISBN: 978-91-87189-50-0
Defence date
26 October 2012
Defence time
09:00
Defence place
Jubileumsaulan, Jan Waldenströms gata 5, Skåne University Hospital, Malmö
Opponent
- Olle Söder