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Enzymatic characterization of lipid-based drug delivery systems

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Author

Summary, in English

The present work introduces a simple and robust in vitro method for enzymatic characterisation of surface properties of lipid dispersions in aqueous media. The initial lipolysis rate in biorelevant media, using pancreatic lipase and a self-microemulsifying formulation (SMEDDS) containing digestible lipids as substrate, was determined. The impact of incorporating two sparingly water soluble model drugs, probucol and halofantrine, into the SMEDDS was studied. It was found that both model drugs reduced the initial rate of lipolysis compared with the vehicle, probucol having a larger effect than halofantrine. The reduction of initial lipolysis rate indicates that probucol and halofantrine are bound in the water/emulsion interface limiting the substrate availability.

Department/s

Publishing year

2005

Language

English

Pages

328-332

Publication/Series

International Journal of Pharmaceutics

Volume

298

Issue

2

Document type

Journal article

Publisher

Elsevier

Topic

  • Food Engineering

Keywords

  • Self-microemulsifying drug delivery system
  • Lipolysis
  • Probucol
  • Halofantrine

Status

Published

ISBN/ISSN/Other

  • ISSN: 1873-3476