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Computational Perspectives on Neuromodulation of Aging

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Author

Summary, in English

Cognitive functions, such as memory, attention, and perception, declines with age. Besides other neuroanatomical changes, the level of dopamine also attenuates during aging. We review how computational modeling can provide insights in how these lifetime changes in dopamine levels is expressed at the behavioral level yielding a bridge across different levels. Results indicate that attenuation of dopamine lowers the signal to noise ratio providing a less distinctive neural representation, and detrimental cognitive performance.

Department/s

Publishing year

2007

Language

English

Pages

513-518

Publication/Series

Acta Neurochirurgica. Supplementum

Volume

97

Document type

Journal article review

Publisher

Springer

Topic

  • Psychology (excluding Applied Psychology)

Keywords

  • cognitive functions
  • neural networks
  • aging
  • neuromodulation
  • Dopamine
  • noise

Status

Published

Research group

  • Lund University Cognitive Science (LUCS)

ISBN/ISSN/Other

  • ISSN: 0065-1419