Heme A biosynthesis
Author
Summary, in English
Respiration in plants, most animals and many aerobic microbes is dependent on heme A. This is a highly specialized type of heme found as prosthetic group in cytochrome a-containing respiratory oxidases. Heme A differs structurally from heme B (protoheme IX) by the presence of a hydroxyethylfarnesyl group instead of a vinyl side group at the C2 position and a formyl group instead of a methyl side group at position C8 of the porphyrin macrocycle. Heme A synthase catalyzes the formation of the formyl side group and is a poorly understood heme-containing membrane bound atypical monooxygenase. This review presents our current understanding of heme A synthesis at the molecular level in mitochondria and aerobic bacteria. This article is part of a Special Issue entitled: Biogenesis/Assembly of Respiratory Enzyme Complexes. (C) 2012 Elsevier B.V. All rights reserved.
Department/s
Publishing year
2012
Language
English
Pages
920-927
Publication/Series
Biochimica et Biophysica Acta - Bioenergetics
Volume
1817
Issue
6
Document type
Journal article review
Publisher
Elsevier
Topic
- Microbiology
Keywords
- Cytochrome biogenesis
- Heme synthesis
- CtaA
- COX15
- Oxidase assembly
Status
Published
ISBN/ISSN/Other
- ISSN: 0005-2728