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Hormonal and immune profiles in blood were unaffected by PHA provocation in suckling and weaning pigs

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Author

Summary, in English

The lectin, phytohaemagglutinin (PHA), from red kidney beans has been shown as an inducer of growth and precocious gastrointestinal (Cl) maturation in suckling animals, thus better preparing piglets for the weaning procedure. PHA exposure results in the release of gut peptide hormones and/or activation of the Cl immune system. The aim of this study was to elucidate the mechanisms of PHA provocation by studying changes in the blood/plasma levels of major gut hormones, immune parameters and acute phase proteins. Suckling, 9-10 day-old, littermate piglets were gavage fed PHA, either in purified or crude form or, as a control, alpha-lactalbumin (n = 5-6 pigs/group) and blood was obtained repeatedly during one week and after weaning at 5 weeks. No significant differences in the blood parameters between PHA-treated pigs in comparison to their time-matched controls were found during the first week after treatment. At weaning significant changes in hormonal (insulin) and immune (WBC) parameters and CRP were observed, however, these effects were independent of earlier PHA treatment. In conclusion, PHA, given enterally as a single dose, did not affect the basal blood parameters analysed, during both the suckling and post-weaning periods in piglets. (C) 2010 Elsevier B.V. All rights reserved.

Department/s

Publishing year

2010

Language

English

Pages

253-256

Publication/Series

Livestock Science

Volume

133

Issue

1-3

Document type

Conference paper

Publisher

Elsevier

Topic

  • Zoology

Keywords

  • Inflammation
  • Phytohaemagglutinin
  • Weaning
  • Intestinal maturation
  • Piglets

Conference name

11th International Symposium on Digestive Physiology of Pigs

Conference date

2009-05-20 - 2009-05-22

Conference place

Costa Daurada, Spain

Status

Published

ISBN/ISSN/Other

  • ISSN: 1871-1413