Efficient removal of platelets from peripheral blood progenitor cell products using a novel micro-chip based acoustophoretic platform.

Summary, in English

Excessive collection of platelets is an unwanted side effect in current centrifugation-based peripheral blood progenitor cell (PBPC) apheresis. We investigated a novel microchip-based acoustophoresis technique, utilizing ultrasonic standing wave forces for the removal of platelets from PBPC products. By applying an acoustic standing wave field onto a continuously flowing cell suspension in a micro channel, cells can be separated from the surrounding media depending on their physical properties.

• Author: Josefina Dykes; Andreas Lenshof; Ingbritt Åstrand-Grundström; Thomas Laurell; Stefan Scheding
• Department/s: Division of Hematology and Transfusion Medicine; Department of Biomedical Engineering; Stem Cell Center; Bone marrow stem cells and cellular therapies; StemTherapy: National Initiative on Stem Cells for Regenerative Therapy; MultiPark: Multidisciplinary research focused on Parkinson´s disease
• Publishing year: 2011
• Language: English
• Publication/Series: PLoS ONE
• Volume: 6
• Issue: 8
• Full text: - 1 MB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/21857996?dopt=Abstract; http://dx.doi.org/10.1371/journal.pone.0023074
• Document type: Journal article
• Publisher: Public Library of Science (PLoS)
• Topic: Cell and Molecular Biology; Hematology
• Status: Published
• Research group: Bone marrow stem cells and cellular therapies
• ISBN/ISSN/Other: ISSN: 1932-6203