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| Title | Oats (Avena sativa) reduce atherogenesis in LDL-receptor-deficient mice. |
| Author/s | Kristina E Andersson, Kaj Svedberg, Marie Lindholm, Rickard Öste, Per Hellstrand |
| Department/s |
Vascular Physiology
Experimental Cardiovascular Research Unit Division of Clinical Chemistry and Pharmacology |
| Full-text | Available as PDF |
| Alternative location (URL) | http://www.ncbi.nlm.nih.gov/pu... Restricted Access (Alternative Location) |
| Alternative location (URL) | http://dx.doi.org/10.1016/j.at... Restricted Access (Alternative Location) |
| Publication/Series | Atherosclerosis |
| Publishing year | 2010 |
| Volume | Jul 1 |
| Pages | 93 - 99 |
| Document type | Journal article |
| Status | published |
| Quality controlled | yes |
| Language | English |
| Abstract English | AIM: The cholesterol-lowering properties of oats, largely ascribed to its contents of soluble fibers, beta-glucans, are well established, whereas effects on atherogenesis are less well elucidated. Oats also contains components with reported antioxidant and anti-inflammatory effects that may affect atherogenesis. In this work we examined effects of oat bran on plasma cholesterol, markers of inflammation, eNOS expression and development of atherosclerosis in LDL-receptor-deficient (LDLr(-/-)) mice. METHODS AND RESULTS: Female LDLr(-/-) mice were fed Western diet+/-oat bran. Two concentrations of oat bran (40 and 27%) were compared regarding effects on plasma lipids. There was a dose-dependent reduction of plasma cholesterol by 42 and 20% with 40 and 27% oat bran, respectively. Both concentrations also lowered plasma triglycerides (by 45 and 33%) and relative levels of plasma LDL+VLDL. The reduction of plasma lipids was accompanied by increased faecal excretion of cholesterol and bile acids. Oat bran (40%) efficiently reduced atherosclerotic lesion area in the descending aorta (-77%) and aortic root (-33%). Plasma levels of fibrinogen and soluble vascular cell adhesion molecule-1 (VCAM-1) were significantly lower, and immunofluorescence of aortic sections revealed a 75% lower expression of VCAM-1 in oat-fed mice. The expression of eNOS protein in the aortic wall was increased in mice fed oat bran. CONCLUSIONS: Oat bran supplemented to a Western diet lowers plasma cholesterol, reduces levels of some inflammatory markers, increases eNOS expression and inhibits atherosclerotic lesion development in LDLr(-/-) mice. It remains to be investigated which components in oats contribute to these effects. |
| Subject |
Medicine and Health Sciences |
| ISBN/ISSN/Other |
ISSN: 1879-1484 |
