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| Title | No Association of VEGF Polymorphims with Alzheimer's Disease |
| Author/s | Sara Landgren, Mona Seibt Palmer, Ingemar Skoog, Lennart Minthon, Anders Wallin, Niels Andreasen, Madeleine Zetterberg, Kaj Blennow, Henrik Zetterberg |
| Department/s |
Clinical Memory Research Unit
|
| Full-text | Full text is not available in this archive |
| Alternative location (URL) | http://dx.doi.org/10.1007/s120... Restricted Access (Alternative Location) |
| Publication/Series | Neuromolecular Medicine |
| Publishing year | 2010 |
| Volume | 12 |
| Issue | 3 |
| Pages | 224 - 228 |
| Document type | Journal article |
| Status | published |
| Quality controlled | yes |
| Language | English |
| Publisher | Humana Press |
| Abstract English | The vascular hypothesis of Alzheimer's disease (AD) has brought the vascular endothelial growth factor (VEGF) into focus. The genomic region including the VEGF gene has been linked to AD and single nucleotide polymorphisms (SNPs) of the VEGF have in previous studies been associated with AD risk. To further evaluate these findings, we genotyped two SNPs in the VEGF gene (rs699947 [-2578]) and rs1570360 [-1154]) by TaqMan Allelic Discrimination in a study sample including AD patients (n = 801) and controls (n = 286). In a subgroup of the population these SNPs were analyzed in relation to APOE epsilon 4 genotype, to cerebrospinal fluid biomarkers (T-tau, P-tau, and beta(42)-Amyloid) as well as to neuropathological markers for AD (neurofibrillary tangles and senile plaques). No significant associations with risk for AD or any of the studied biomarkers could be found in this study, thus not supporting VEGF as being a major risk gene for AD. |
| Subject |
Medicine and Health Sciences |
| Keywords | VEGF, Alzheimer's disease, beta-Amyloid, Tau |
| ISBN/ISSN/Other |
ISSN: 1535-1084 |
