Your most visited
- Sorry, this tool will only work with Javascript available.
| Title | Mathematical modeling and statistical analysis of calcium-regulated insulin granule exocytosis in beta-cells from mice and humans. |
| Author/s | Morten Gram Pedersen, Giuliana Cortese, Lena Eliasson |
| Department/s |
Islet cell exocytosis
|
| Full-text | Available as PDF |
| Alternative location (URL) | http://www.ncbi.nlm.nih.gov/pu... Restricted Access (Alternative Location) |
| Alternative location (URL) | http://dx.doi.org/10.1016/j.pb... Restricted Access (Alternative Location) |
| Publication/Series | Progress in biophysics and molecular biology |
| Publishing year | 2011 |
| Volume | 107 |
| Issue | 2 |
| Pages | 257 - 264 |
| Document type | Journal article |
| Status | published |
| Quality controlled | yes |
| Language | English |
| Publisher | Elsevier |
| Abstract English | Insulin is released from pancreatic beta-cells as a result of Ca(2+)-evoked exocytosis of dense-core granules. Secretion is biphasic, which has been suggested to correspond to the release of different granule pools. Here we review and carefully reanalyze previously published patch-clamp data on depolarization-evoked Ca(2+)-currents and corresponding capacitance measurements. Using a statistical mixed-effects model, we show that the data indicate that pool depletion is negligible in response to short depolarizations in mouse beta-cells. We then review mathematical models of granule dynamics and exocytosis in rodent beta-cells and present a mathematical description of Ca(2+)-evoked exocytosis in human beta-cells, which show clear differences to their rodent counterparts. The model suggests that L- and P/Q-type Ca(2+)-channels are involved to a similar degree in exocytosis during electrical activity in human beta-cells. |
| Subject |
Medicine and Health Sciences |
| ISBN/ISSN/Other |
ISSN: 1873-1732 |
