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Theses, dissertations and research publications (including journal articles, conference abstracts and books) from Lund University are collected in this database. Where possible, the option to download a full text document is available. It is also possible to search for Lund University student theses in the student theses database.
| Title | Effect of Conditioned Stimulus Parameters on Timing of Conditioned Purkinje Cell Responses. |
| Author/s | Pär Svensson, Dan-Anders Jirenhed, Fredrik Bengtsson, Germund Hesslow |
| Department/s |
Associative Learning
Department of Experimental Medical Science |
| Full-text | Full text is not available in this archive |
| Alternative location (URL) | http://www.ncbi.nlm.nih.gov/pu... Restricted Access (Alternative Location) |
| Alternative location (URL) | http://dx.doi.org/10.1152/jn.0... Restricted Access (Alternative Location) |
| Publication/Series | Journal of neurophysiology |
| Publishing year | 2010 |
| Volume | 103 |
| Pages | 1329 - 1336 |
| Document type | Journal article |
| Status | published |
| Quality controlled | yes |
| Language | English |
| Abstract English | Pavlovian eyeblink conditioning is a useful experimental model for studying adaptive timing, an important aspect of skilled movements. The conditioned response (CR) is precisely timed to occur just before the onset of the expected unconditioned stimulus (US). The timing can be changed immediately, however, by varying parameters of the conditioned stimulus (CS). It has previously been shown that increasing the intensity of a peripheral CS or the frequency of a CS consisting of a train of stimuli to the mossy fibers shortens the latency of the CR. The adaptive timing of behavioral CRs probably reflects the timing of an underlying learned inhibitory response in cerebellar Purkinje cells. It is not known how the latency of this Purkinje cell CR is controlled. We have recorded form Purkinje cells in conditioned decerebrate ferrets while increasing the intensity of a peripheral CS or the frequency of a mossy fiber CS. We observe changes in the timing of the Purkinje cell CR that match the behavioral effects. The results are consistent with the effect of CS parameters on behavioral CR latency being caused by corresponding changes in Purkinje cell CRs. They suggest that synaptic temporal summation may be one of several mechanisms underlying adaptive timing of movements. |
| Subject |
Medicine and Health Sciences |
| ISBN/ISSN/Other |
ISSN: 1522-1598 |
| Project | Cognition, Communication and Learning |
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