Jörgen Eriksson
Kristoffer Holmqvist
Mikael Graffner
Email: publicera@lub.lu.se
+46 (0)46 222 0326
Your most visited
- Sorry, this tool will only work with Javascript available.
Find Publications
Theses, dissertations and research publications (including journal articles, conference abstracts and books) from Lund University are collected in this database. Where possible, the option to download a full text document is available. It is also possible to search for Lund University student theses in the student theses database.
| Title | Time Course of Classically Conditioned Purkinje Cell Response is Determined by Initial Part of Conditioned Stimulus |
| Author/s | Dan-Anders Jirenhed, Germund Hesslow |
| Department/s |
Department of Experimental Medical Science
Associative Learning |
| Full-text | Available as PDF |
| Alternative location (URL) | http://dx.doi.org/10.1523/JNEU... Restricted Access (Alternative Location) |
| Publication/Series | Journal of Neuroscience |
| Publishing year | 2011 |
| Volume | 31 |
| Issue | 25 |
| Pages | 9070 - 9074 |
| Document type | Journal article |
| Status | published |
| Quality controlled | yes |
| Language | English |
| Publisher | Society for Neuroscience |
| Abstract English | Classical conditioning of a motor response such as eyeblink is associated with the development of a pause in cerebellar Purkinje cell firing that is probably an important driver of the overt response. This conditioned Purkinje cell response is adaptively timed and has a specific temporal profile that probably explains the time course of the overt behavior. It is generally assumed that the temporal properties of the conditioned Purkinje cell response are determined by the temporal pattern of the parallel fiber impulses generated by the conditioned stimulus at the time of the conditioned response. We show here in the decerebrate ferret preparation that a very brief conditioned stimulus, consisting of only one or two impulses in the mossy fibers, can be sufficient to elicit a full conditioned Purkinje cell response with normal time course. The finding suggests that parallel fiber input to the Purkinje cell influences the firing rate several hundred milliseconds later. It poses a serious challenge to the standard view of the role of parallel fiber impulses in response timing. |
| Subject |
Biology and Life Sciences Medicine and Health Sciences |
| Keywords | Purkinje cell – Classical Conditioning – Temporal coding - Cerebellum – Motor learning – Eyeblink - Ferret |
| ISBN/ISSN/Other |
ISSN: 1529-2401 |
| Project | Cognition, Communication and Learning |
| Funder |
VR |
Contact
"ReSearch for the Future"
Lund University's "ReSearch for the Future" magazine (Pdf, 10 Mb) presents a range of research from across the University.