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Thousands of new findings contribute to a global virus map

Street view in New York
Photo: Unsplash

An extensive study has mapped RNA viruses in a large number of cities around the world. The researchers identified nearly 55,000 different types of virus, the vast majority of which had never been observed before. The virus atlas could be useful in both biological risk assessment and crime scene investigations.

 

Surprisingly little is known about how virus populations are distributed across the planet


The new research study has produced the first large-scale atlas of RNA viruses in cities and their surrounding areas. RNA viruses are a group of viruses whose genetic material consists of a single-stranded RNA molecule. The data set comprises a total of 102 cities in 31 countries.

“Tell me which city you live in and I’ll tell you which viruses you’re carrying,” says Eran Elhaik, a researcher in genetics at Lund University.

The statement may sound like a joke, but Eran Elhaik has good grounds for the claim when it comes to the cities included in the new international study - led by East China Normal University in Shanghai, China. Researchers around the world have analysed around 3,000 samples collected from public places, such as bus and train stations, banks and hospitals.

Man with gloves sampling a bench
Around 3,000 samples have been collected. The new virus map could prove valuable for environmental monitoring and forensic investigations. (Photo: Eran Elhaik)

Through their analysis, the researchers have been able to establish which RNA viruses are present at the various locations. Based on this data, the researchers have subsequently been able to create a global virus atlas showing the prevalence of various RNA viruses in the cities included in the study. 

The value of a viral landscape

Most viruses do not infect humans. Nevertheless, Eran Elhaik believes there is great value in mapping the different virus strains and their prevalence. Such knowledge can be used, for example, in forensic investigations in connection with a crime. Virus analysis can then provide the police with more clues and a better chance of linking a person or an object to a specific location.

A global virus atlas can also be useful in various forms of environmental monitoring where it is necessary to keep track of biological threats - or example, in the event of environmental changes that may have a negative impact on nature.

“Having a virus atlas that shows what the viral landscape in an area usually looks like can be a valuable frame of reference for detecting any abnormalities that may arise,” says Eran Elhaik.

In the study, the researchers identified nearly 55,000 different virus variants. Almost 80 per cent of them had never been observed before and were therefore unknown to science.

An unexplored world

Both viruses and bacteria remain a world yet to be explored. Although a great deal of research has already been carried out into microorganisms, only a very small proportion of these organisms have been identified, classified and studied in terms of their geographical distribution.

“Surprisingly little is known about how virus populations are distributed across the planet,” says Eran Elhaik.

The current research study clearly shows that viruses are not evenly distributed across the world. Different cities and their surrounding areas are home to different virus populations, which are shaped by geography, local environments and human activity.

“Every city has its own unique viral landscape. This gives us a sort of viral fingerprint that is specific to each individual location,” concludes Eran Elhaik.

 

Contact:

Eran Elhaik


Eran Elhaik
Senior lecturer at Evolutionary Ecology and Infection Biology
Lund University
eran [dot] elhaik [at] biol [dot] lu [dot] se (eran[dot]elhaik[at]biol[dot]lu[dot]se)

Who carried out the study?

The study was carried out by researchers from 24 countries in Europe, Asia, North America, South America and Africa. The research was carried out through the international MetaSUB consortium, a group that conducts wide-ranging research into, and raises awareness of, microbial ecosystems in urban environments.

What are RNA viruses?

RNA viruses consist of a single-stranded RNA molecule, unlike DNA viruses, which are made up of a double-stranded DNA molecule. Some well-known RNA viruses include the influenza virus, HIV, common cold viruses and the coronavirus that causes COVID-19. All types of viruses exist in a grey area between being defined as living or not. Unlike animals, fungi and bacteria, they do not have their own metabolism and cannot reproduce on their own. Instead, they must infect living cells in order to continue to exist.

Environmental DNA

Eran Elhaik was also in the news this spring after developing a new technique which, using environmental DNA, is expected to provide the police with valuable leads in forensic investigations. Environmental DNA contains traces of bacteria, viruses, fungi and pollen. This technology is based on the same fundamental principle as the new global virus atlas, namely using new knowledge about the distribution of microorganisms to create tools that can provide geographical information in various contexts.