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IPSC Laboratory for CNS Disease Modeling

Faculty of Medicine / Department of Experimental Medical Science
Website: https://www.ipsc-cns-disease.lu.se/

Visiting address: Sölvegatan 19, BMC D10, 221 84 Lund

IPSC Laboratory for CNS Disease Modeling's profile in Lund University Research portal

Description

Research in the laboratory attempts to define pathogenic cellular and molecular mechanisms involved in synucleiopathies, in particular Parkinson's disease and multiple system atrophy, and Alzheimer's disease. To this aim, we generate induced pluripotent stem cells (iPSC) from patients, which we utilize to understand cell autonomous and non-cell autonomous processes that lead to neuronal damage. By generating iPSCs from patients suffering familial and idiopathic forms of the diseases, we aim to elucidate causative mechanisms leading to neural cell dysfunction, and neurodegeneration. Our cutting-edge approach will allow for the identification of new molecular targets, which could be used for the development of new diagnostic tools for early diagnosis, as well as for the stratification and recruitment of patients for future clinical trials.

Coworkers

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  • Carla Azevedo

    Visiting research fellow

    carla [dot] azevedo [at] med [dot] lu [dot] se

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  • Erika Velásquez

    Visiting research fellow

    erika [dot] velasquez [at] med [dot] lu [dot] se