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Neural stem cells

Faculty of Medicine / Department of Experimental Medical Science
Website: https://www.stemcellcenter.lu.se/research-groups/falk

Visiting address: Sölvegatan 19, 221 84 Lund

Postal address: Box 118, 221 00 Lund

Neural stem cells' profile in Lund University Research portal

Description

Reprogramming somatic cells to induced pluripotent stem (iPS) cells and directed differentiation opens up for studies on neural cells from patients. The Falk group is focusing on fundamental questions in early human neurogenesis. We build cellular models of the healthy and diseased human brain using reprogrammed patient cells. We derive patient specific iPS cells that are further differentiated into patient specific neuroepithelial stem (NES) cells or into 3D brain organoids. We use the cellular models to study proliferation, self-renewal, and differentiation potential as well as the maturation and function of derived neurons to uncover disease mechanisms. The Neural Stem Cells lab is also driving translational projects investigating the regenerative potential of iPS cell derived neural cells in preclinical models with the aim to create ATMPs to take iPS derived cell to clinic. We have derived one of few clinical compliant GMP iPS cell lines that we have banked in a master bank.

Staff

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  • Alice Hägg

    Doctoral student

    alice [dot] hagg [at] med [dot] lu [dot] se

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  • Elias Uhlin

    Project manager

    elias [dot] uhlin [at] med [dot] lu [dot] se