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The role of biomechanics in the initiation and progression of OA of the knee.

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Author

Summary, in English

The knee is one of the most common joints affected by osteoarthritis (OA), frequently with clinical presentation by middle age or even earlier. Accumulating evidence supports that knee OA progression is often driven by biomechanical forces, and the pathological response of tissues to such forces leads to structural joint deterioration, knee symptoms and reduced function. Well-known biomechanical risk factors for progression include joint malalignment and meniscal tear. The high risk of OA after knee injury demonstrates the critical role of biomechanical factors also in incident disease in susceptible individuals. However, our knowledge of the contributing biomechanical mechanisms in the development of early disease and their order of significance is limited. Part of the problem is our current lack of understanding of early-stage OA, when it starts and how to define it.

Publishing year

2010

Language

English

Pages

39-46

Publication/Series

Baillière's Best Practice & Research: Clinical Rheumatology

Volume

24

Issue

1

Document type

Journal article

Publisher

Baillière Tindall

Topic

  • Rheumatology and Autoimmunity

Status

Published

ISBN/ISSN/Other

  • ISSN: 1532-1770