The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Polymorphism within the interferon-gamma/receptor complex is associated with pulmonary tuberculosis

Author

  • Graham S Cooke
  • Sarah J Campbell
  • Jackson Sillah
  • Per Gustafson
  • Boubacar Bah
  • Georgio Sirugo
  • Steve Bennett
  • Keith P W J McAdam
  • Oumou Sow
  • Christian Lienhardt
  • Adrian V S Hill

Summary, in English

RATIONALE: Interferon-gamma (IFN-gamma) is of central interest in the study of tuberculosis. A number of single-gene mutations have been identified in the IFN-gamma signaling pathway that predispose to severe mycobacterial disease, but the relevance of polymorphism within these genes to the common phenotype of tuberculosis remains unclear. METHODS: A total of 1,301 individuals were included in a large, detailed study of West African populations with pulmonary tuberculosis. We investigated disease association with the genes encoding IFN-gamma and its receptor subunits (IFNG, IFNGR1, and IFNGR2). RESULTS: Within the IFNG gene, two promoter variants showed evidence of novel disease association: -1616GG (odds ratio [OR], 1.49; 95% confidence interval [CI], 1.11-2.00; p = 0.008) and +3234TT (OR, 1.40; 95% CI, 1.09-1.80; p = 0.009). The +874AA genotype was not significantly more frequent among cases over control subjects (OR, 1.16; 95%CI, 0.89-1.51; p = 0.25). In addition, novel disease association was also found with the -56CC genotype of the IFNGR1 promoter (OR, 0.75; 95% CI, 0.57-0.99; p = 0.041). No disease association was seen with the IFNGR2 locus. CONCLUSIONS: These results provide evidence of a significant role for genetic variation at the IFNG locus and provide detailed understanding of the genetic mechanisms underlying this association. The disease association with IFNGR1 is novel, and together these findings support the hypothesis that genetically determined variation in both IFN-gamma production and responsiveness influences the risk of developing tuberculosis.

Department/s

  • Infectious Diseases Research Unit

Publishing year

2006

Language

English

Pages

339-343

Publication/Series

American Journal of Respiratory and Critical Care Medicine

Volume

174

Issue

3

Document type

Journal article

Publisher

American Thoracic Society

Topic

  • Respiratory Medicine and Allergy

Keywords

  • receptor
  • interferon-gamma
  • polymorphism
  • tuberculosis

Status

Published

Research group

  • Infectious Diseases Research Unit

ISBN/ISSN/Other

  • ISSN: 1535-4970