Hemodynamic Aging as the Consequence of Structural Changes Associated with Early Vascular Aging (EVA).
Author
Summary, in English
An increase in peripheral vascular resistance at rest is not routinely observed in healthy older persons, but often associated with increased stiffness of central elastic arteries, as hallmarks of aging effects on the vasculature, referred to as early vascular aging (EVA). In clinical practice, the increased arterial stiffness translates into increased brachial and central systolic blood pressure and corresponding pulse pressure in subjects above 50 years of age, as well as increased carotid-femoral pulse wave velocity (c-f PWV), a marker of arterial stiffness. A c-f PWV value ≥ 10 m/s is currently defined as a threshold for increased cardiovascular risk, based on consensus statement from 2012. Prevention and treatment strategies include a healthy lifestyle and the control of risk factors via appropriate drug therapy to achieve vascular protection related to EVA. New drugs are under development for vascular protection, for example the selective Angiotensin II (AT2) receptor agonist called compound 21. One target group for early intervention could be members of risk families including subjects with early onset cardiovascular disease.
Publishing year
2014
Language
English
Pages
109-113
Publication/Series
Aging and Disease
Volume
5
Issue
2
Full text
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Document type
Journal article review
Publisher
Buck Institute for Age Research
Topic
- Geriatrics
Status
Published
Research group
- Internal Medicine - Epidemiology
ISBN/ISSN/Other
- ISSN: 2152-5250