Lung function in smokers - Aspects on COPD diagnosis and associations to atherosclerosis and alcohol consumption
Summary, in English
The aim of this thesis was to analyse extensive lung function tests in a population withmany smokers with light or no decrease in lung function with special reference to COPD diagnosis and association to atherosclerosis and alcohol consumption.
From a previous population-based respiratory questionnaire survey 450 subjects were recruited (never-smokers and smokers, with/without self-reported COPD) and examined with spirometry, body plethysmography, diffusing capacity for CO (DL,CO), IOS and ultrasonography of the internal carotid artery. They also answered questionnaires and
blood samples were collected.
The results show differences in DL,CO, residual volume and respiratory symptoms between subjects fulfilling none, either or both of the diagnostic spirometric criteria for COPD in use. (paper I). Pulmonary resistance is higher in symptomatic subjects, irrespective of a spirometric COPD diagnosis or not (paper II). Subjects with atherosclerotic plaques in the ICA have lower DL,CO and higher residual volume than subjects without plaques(paper
III). Among smokers, heavy drinking is associated with lower DL,CO and forced expiratory volume in one second (FEV1) (paper IV).
In conclusion, this thesis shows that other aspects of lung function in smokers than FEV1 are of value in both COPD diagnosis and in understanding associations to atherosclerosis and alcohol consumption.
Lund University Faculty of Medicine Doctoral Dissertation Series
Clinical Physiology and Nuclear Medicine Unit
- Radiology, Nuclear Medicine and Medical Imaging
- Lung function
- alcohol consumption
- Clinical Physiology, Malmö
- ISSN: 1652-8220
- ISBN: 978-91-87651-85-4
23 May 2014
Room 2007, Inga Marie Nilssons gata 49, SUS Malmö
- Hans Hedenström (Docent)