Studies of different secondary metabolites : Natural products from the mevalonate pathway
Author
Summary, in English
Due to their bioactivity, natural products present in medicinal plants, mushrooms (and other organisms such as bacteria and algae) have been the source of medicine and the inspiration of modern dug discovery since they are characterized by an enormous scaffold diversity and structural complexity.
In the search of new natural products, this thesis comprises the study of natural products from two fungal species, Aleurodiscus sp. and Galiella Rufa.
From Aleurodiscus sp., 8 molecules in total were isolated, belonging to the benzofuran, chromane and chromene-type compounds.
From G. rufa no novel molecules were isolated since its chemistry is well known, however, this thesis comprises the use of its enzymatic potential to biotransform synthetic analogues of desoxygaliellalactone into galiellalactone and galiellalactam analogues.
Finally, from the medicinal plant Trichilia adolfi, nine novel limonoids-type natural products were isolated and evaluated as anti-parasitic agents.
Department/s
Publishing year
2021-06-04
Language
English
Full text
- Available as PDF - 35 MB
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Document type
Dissertation
Publisher
Lund University
Topic
- Organic Chemistry
Keywords
- Natural products
- fungi
- Galiellalactone
- Galiella rufa
- Trichilia adolfi
- benzofuran
Status
Published
Supervisor
ISBN/ISSN/Other
- ISBN: 978-91-7895-936-5
- ISBN: 978-91-7895-935-8
Defence date
26 August 2021
Defence time
14:00
Defence place
Kemicentrum Sal C Join via zoom: https://lu-se.zoom.us/j/69776660302?pwd=Zzg2bnVqbTliUkFpZ1dsdFp6WlJGdz09
Opponent
- Luis Manuel Peña Rodríguez (Doctor)