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Simulated Mid-ranging Control of Propofol and Remifentanil using EEG-measured Hypnotic Depth of Anesthesia

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Author

Summary, in English

This paper suggests an extension of an existing, clinically evaluated, closed-loop drug delivery system for hypnotic depth control using propofol. The extension introduces closed-loop administration of the analgesic drug remifentanil, thus forming a multiple input–single output (MISO) control system. Remifentanil acts and is metabolized at a significantly faster time scale than propofol. Direct control of analgesia is hindered by the current absence of a reliable real-time nociception monitor. However, several hypnotic depth monitors respond to nociception. Sudden changes in the measured hypnotic depth are frequently caused by changes in noxious stimulation. The novelty of this work lies in increasing the disturbance rejection bandwidth of the control system for hypnotic depth by directing the high frequency content of its control error to a remifentanil controller. Such a mid-ranging control system was implemented and tuned based on 23 patient models obtained from a previous clinical study and its performance is demonstrated through a simulation study.

Publishing year

2012

Language

English

Pages

356-361

Publication/Series

51st IEEE Conference on Decision and Control

Document type

Conference paper

Publisher

IEEE - Institute of Electrical and Electronics Engineers Inc.

Topic

  • Control Engineering

Keywords

  • Medical control systems
  • Drug delivery
  • Control system synthesis
  • Medical simulation

Conference name

51st IEEE Conference on Decision and Control, 2012

Conference date

2012-12-10 - 2012-12-13

Conference place

Maui, Hawaii, United States

Status

Published

Project

  • Anesthesia in Closed Loop
  • LCCC

Research group

  • LCCC

ISBN/ISSN/Other

  • ISSN: 0191-2216
  • ISBN: 978-1-4673-2064-1