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Standardization and Utilization of Biobank Resources in Clinical Protein Sciene with Examples of Emerging Applications

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Author

Summary, in English

Biobanks are a major resource to access and measure biological constituents that can be used to monitor the status of health and disease, both in unique individual samples and within populations. Most “omic” activities rely on access to these collections of stored samples to provide the basis for establishing the ranges and frequencies of expression. Furthermore, information about the relative abundance and form of protein constituents found in stored samples provides an important historical index for comparative studies of inherited, epidemic, and developing disease. Standardizations of sample quality, form, and analysis are an important unmet need and requirement for gaining full benefit from collected samples. Coupled to this standard is the provision of annotation describing clinical status and metadata of measurements of clinical phenotype that characterizes the sample. Today we have not yet achieved consensus on how to collect, manage, and build biobank archives in order to reach goals where these efforts are translated into value for the patient. Several initiatives (OBBR, ISBER, BBMRI) that disseminate best practice examples for biobanking are expected to play an important role in ensuring the need to preserve the sample integrity of biosamples stored for periods that reach one or several decades. These developments will be of great value and importance to programs such as the Chromosome Human Protein Project (C-HPP) that will associate protein expression in healthy and disease states with genetic foci along of each of the human chromosomes.

Department/s

Publishing year

2012

Language

English

Pages

5124-5134

Publication/Series

Journal of Proteome Research

Volume

11

Issue

11

Document type

Journal article

Publisher

The American Chemical Society (ACS)

Topic

  • Cancer and Oncology

Keywords

  • Biobank
  • Healthcare
  • Disease
  • Biomarkers
  • Protein
  • Human Proteome Project
  • Biological specimen banks
  • Biological Specimen Banks/ethics
  • Biological Specimen Banks/legislation & jurisprudence
  • Biomedical Research/ethics
  • Ethical review
  • Government regulation
  • Humans
  • Informed consent
  • Tissue donors
  • Ethics

Status

Published

ISBN/ISSN/Other

  • ISSN: 1535-3893