On the origin of mitochondria: a genomics perspective.
Author
Summary, in English
The availability of complete genome sequence data from both bacteria and eukaryotes provides information about the contribution of bacterial genes to the origin and evolution of mitochondria. Phylogenetic analyses based on genes located in the mitochondrial genome indicate that these genes originated from within the f-proteobacteria. A number of ancestral bacterial genes have also been transferred from the mitochondrial to the nuclear genome, as evidenced by the presence of orthologous genes in the mitochondrial genome in some species and in the nuclear genome of other species. However, a multitude of mitochondrial proteins encoded in the nucleus display no homology to bacterial proteins, indicating that these originated within the eukaryotic cell subsequent to the acquisition of the endosymbiont. An analysis of the expression patterns of yeast nuclear genes coding for mitochondrial proteins has shown that genes predicted to be of eukaryotic origin are mainly translated on polysomes that are free in the cytosol whereas those of putative bacterial origin are translated on polysomes attached to the mitochondrion. The strong relationship with f-proteobacterial genes observed for some mitochondrial genes, combined with the lack of such a relationship for others, indicates that the modern mitochondrial proteome is the product of both reductive and expansive processes.
Department/s
Publishing year
2003
Language
English
Pages
165-177
Publication/Series
Philosophical Transactions of the Royal Society B: Biological Sciences
Volume
358
Issue
1429
Document type
Journal article
Publisher
Royal Society Publishing
Topic
- Biological Sciences
Keywords
- respiration
- mitochondria
- glycolysis
- hydrogenosomes
- yeast
Status
Published
Research group
- Microbial Ecology
ISBN/ISSN/Other
- ISSN: 1471-2970