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Fatty-acid-displaced transcriptional repressor, a conserved regulator of cytochrome P450 102 transcription in Bacillus species

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Author

Summary, in English

Bacillus subtilis strain 168 encodes two flavocytochromes P450, Cyp102A2 and Cyp102A3. The cyp102A3 gene is preceded by, and organized in an operon with, a gene for a transcriptional regulator, encoded by fatR. The paralogous gene, cyp102A2, is most likely transcribed as a mono-cistronic message. We show that fatR encodes a protein that binds to an operator sequence that is present upstream of its own reading frame, thereby repressing the expression of the fatR-cyp102A3 operon. Unsaturated fatty acids and phytanic acid have the capacity to interact with FatR and to abrogate its binding to the operator sequence.

Publishing year

2001

Language

English

Pages

459-464

Publication/Series

Archives of Microbiology

Volume

176

Issue

6

Document type

Journal article

Publisher

Springer

Topic

  • Immunology in the medical area
  • Microbiology in the medical area

Keywords

  • Cyp102A2
  • Cyp102A1
  • FatR
  • Bacillus subtilis
  • cytochrome P450
  • P450BM-3
  • Cyp102A3

Status

Published

Research group

  • Microbiology Group

ISBN/ISSN/Other

  • ISSN: 0302-8933