Identification of Novel Spinal Cholinergic Genetic Subtypes Disclose Chodl and Pitx2 as Markers for Fast Motor Neurons and Partition Cells
Author
Summary, in English
Spinal cholinergic neurons are critical for motor function in both the autonomic and somatic nervous systems and are affected in spinal cord injury and in diseases such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy. Using two screening approaches and in situ hybridization, we identified 159 genes expressed in typical cholinergic patterns in the spinal cord. These include two general cholinergic neuron markers, one gene exclusively expressed in motor neurons, and nine genes expressed in unknown sub-types of somatic motor neurons. Further, we present evidence that chondrolectin (Chodl) is expressed by fast motor neurons and that estrogen-related receptor beta (ERR beta) is a candidate marker for slow motor neurons. In addition, we suggest paired-like homeodomain transcription factor 2 (Pitx2) as a marker for cholinergic partition cells. J. Comp. Neurol. 518:2284-2304, 2010. (C) 2010 Wiley-Liss, Inc.
Department/s
Publishing year
2010
Language
English
Pages
2284-2304
Publication/Series
Journal of Comparative Neurology
Volume
518
Issue
12
Document type
Journal article
Publisher
John Wiley & Sons Inc.
Topic
- Neurology
Keywords
- cord
- spinal
- motor neuron
- interneuron
- mouse genetics
- neuronal network
- genetic screen
Status
Published
ISBN/ISSN/Other
- ISSN: 1096-9861