Measuring genome conservation across taxa: divided strains and united kingdoms
Author
Summary, in English
Species evolutionary relationships have traditionally been defined by sequence similarities of phylogenetic marker molecules, recently followed by whole-genome phylogenies based on gene order, average ortholog similarity or gene content. Here, we introduce genome conservation—a novel metric of evolutionary distances between species that simultaneously takes into account, both gene content and sequence similarity at the whole-genome level. Genome conservation represents a robust distance measure, as demonstrated by accurate phylogenetic reconstructions. The genome conservation matrix for all presently sequenced organisms exhibits a remarkable ability to define evolutionary relationships across all taxonomic ranges. An assessment of taxonomic ranks with genome conservation shows that certain ranks are inadequately described and raises the possibility for a more precise and quantitative taxonomy in the future. All phylogenetic reconstructions are available at the genome phylogeny server: <http://maine.ebi.ac.uk:8000/cgi-bin/gps/GPS.pl>.
Department/s
Publishing year
2005
Language
English
Pages
616-621
Publication/Series
Nucleic Acids Research
Volume
33
Issue
2
Links
Document type
Journal article
Publisher
Oxford University Press
Topic
- Biological Sciences
Keywords
- genome phylogeny
- Comparative genomics
- evolution
- Bioinformatics
Status
Published
Research group
- Microbial Ecology
ISBN/ISSN/Other
- ISSN: 1362-4962