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Study of ATP-release from acoustically levitated eryhrocytes

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Author

Editor

  • Jean-Louis Viovy
  • Patrick Tabeling
  • Stephanie Descroix
  • Laurent Malaquin

Summary, in English

Erythrocytes (red blood cells) are known to produce large amounts of Adenosine Triphosphate (ATP). It has recently become clear that the ATP-release is part of a mechanism controlling the dilation of the body’s blood vessels. The study of the erythrocyte’s behaviour is complicated by the fact that they respond easily to any physical contact. In this paper we propose a new method for studying the dynamics of the ATP-release by combining non-contact acoustic trapping in a microfluidic chip with a chemiluminiscent assay. Sensitivity levels down to 10 pM were achievable and the ATP-release from a cluster of levitated live erythrocytes was recorded.

Publishing year

2007

Language

English

Pages

1372-1374

Publication/Series

The proceedings of micro total analysis systems 2007

Volume

2

Document type

Conference paper

Publisher

Chemical and Biological Microsystems Society

Topic

  • Medical Engineering

Keywords

  • Chemiluminiscence
  • Erythrocytes
  • ATP
  • Acoustic trapping

Conference name

Micro Total Analysis Systems 2007

Conference date

2007-10-07 - 2007-10-11

Status

Published

ISBN/ISSN/Other

  • ISBN: 978-0-9798064-0-7