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Autofluorescence insensitive imaging using upconverting nanocrystals in scattering media

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Author

  • Can Xu
  • Niclas Svensson
  • Johan Axelsson
  • Pontus Svenmarker
  • Gabriel Somesfalean
  • Guanying Chen
  • Huijuan Liang
  • Haichun Liu
  • Zhiguo Zhang
  • Stefan Andersson-Engels

Summary, in English

Autofluorescence is a nuisance in the field of fluorescence imaging and tomography of exogenous molecular markers in tissue, degrading the quality of the collected data. In this letter, we report autofluorescence insensitive imaging using highly efficient upconverting nanocrystals (NaYF4: Yb3+ /Tm3+) in a tissue phantom illuminated with near- infrared radiation of 85 mW/cm(2). It was found that imaging with such nanocrystals leads to an exceptionally high contrast compared to traditional downconverting fluorophores due to the absence of autofluorescence. Upconverting nanocrystals may be envisaged as important biological markers for tissue imaging purposes. c 2008 American Institute of Physics. [DOI: 10.1063/1.3005588]

Department/s

Publishing year

2008

Language

English

Publication/Series

Applied Physics Letters

Volume

93

Issue

17

Document type

Journal article

Publisher

American Institute of Physics (AIP)

Topic

  • Atom and Molecular Physics and Optics

Status

Published

Research group

  • Biophotonics

ISBN/ISSN/Other

  • ISSN: 0003-6951