The role of p-c-Jun in survival and outgrowth of developing sensory neurons
Author
Summary, in English
c-jun activation has been implicated not only in neuronal apoptosis, but also in survival and regeneration. This Janus facet of c-Jun activation could be related to neuronal cell type or to the developmental stage of the neuron. We investigated c-Jun activation in E18 sensory neurons. Cultures of rat dorsal root ganglia neurons were maintained with or without the addition of nerve growth factor or the c-Jun N-terminal kinase inhibitor, (D)-JNKII. Few dorsal root ganglia neurons survived nerve growth factor deprivation, whereas neurons supplied with nerve growth factor survived and exhibited extensive axonal outgrowth. Activated c-Jun was present in the nuclei of neurons with regenerating axons, but not in apoptotic neurons. c-Jun N-terminal kinase inhibition reduced the number of p-c-Jun immunoreactive and regenerating neurons, and increased cell death. Thus, activation of c-Jun seems to be required for survival and regeneration of developing sensory neurons.
Department/s
Publishing year
2005
Language
English
Pages
1655-1659
Publication/Series
NeuroReport
Volume
16
Issue
15
Document type
Journal article
Publisher
Lippincott Williams & Wilkins
Topic
- Neurosciences
Keywords
- nerve growth
- dorsal root ganglia
- development
- c-Jun
- (D)-JNKII
- rat
- factor
Status
Published
ISBN/ISSN/Other
- ISSN: 1473-558X