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Monoamine theories of depression: historical impact on biomedical research

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Author

Summary, in English

Monoamine theories associate depression with reduced brain monoamine levels. These theories achieved broad popularity in the mid-1960s. The present article reviews the historical development of monoamine theories and their subsequent impact on biomedical research. Alleged divisions between West European and U.S. researchers over competing versions of the theories are investigated using bibliometrics. Subsequently, the application of monoamine theories in the NIMH Collaborative Program on the Psychobiology of Depression is covered. The paper argues that the impact of monoamine theories is best explained by the ability of researchers, governmental agencies and pharmaceutical companies to invoke theories that advance various projects and agendas.

Publishing year

2012

Language

English

Pages

366-392

Publication/Series

Journal of the History of the Neurosciences

Volume

21

Issue

4

Document type

Journal article

Publisher

Psychology Press

Topic

  • Gender Studies

Keywords

  • depression
  • biological psychiatry
  • history
  • monoamine hypothesis
  • monoamine theory
  • Psychobiology of Depression Program
  • NIMH
  • bibliometrics

Status

Published

Project

  • After the success with the new generation antidepressants: Experiences, practices, discourses and changes in the self.

ISBN/ISSN/Other

  • ISSN: 0964-704X