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Changes in the Levels of Neurospecific Proteins and in Behavioral Phenomena in Rats with Hepatic Encephalopathy

Author

Summary, in English

We showed that, under conditions of experimental chronic hepatitis, excessive increases in the levels of a Ca-binding protein, S-100b, and a neuronal cell adhesion molecule, NCAM, occur in all parts of the brain of Wistar rats. This is accompanied by suppression of locomotor and orientational/research activity of the animals and increase in their stress sensitivity. Treatment by a ketoglutarate and cytoflavin in chronic hepatitis provides a clear neuroprotective effect.

Department/s

Publishing year

2011

Language

English

Pages

205-208

Publication/Series

Neurophysiology

Volume

43

Issue

3

Document type

Journal article

Publisher

Springer

Topic

  • Zoology

Keywords

  • hepatic encephalopathy
  • S-100b
  • NCAM
  • behavior

Status

Published

ISBN/ISSN/Other

  • ISSN: 0090-2977