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Neural regeneration along longitudinal polyglactin sutures across short and extended defects in the rat sciatic nerve

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Author

Summary, in English

Object. The authors have previously shown that longitudinal sutures without artificial tube support regeneration across a 7-mm gap in the rat sciatic nerve. In the present study, the authors, compared this new approach with the use of autologous nerve grafts across short defects and examined whether the approach could be used to support regeneration across extended gaps and whether the interposition of a short nerve segment (the stepping-stone procedure) was applicable in this model. Methods. Longitudinal sutures were used to bridge 7- and 15-mm gaps in the rat sciatic nerve. Contralateral comparisons were made to nerve autografts in the 7-mm group and to sutures plus a short interposed nerve segment in the 15-mm group. Regeneration was evaluated at 2, 4, and 12 weeks by using immunocytochemical analysis for Schwann cells, neurofilament protein, and macrophages and at 12 weeks also by using histological examination, including morphometry in the distal tibial trunk and tetanic force measurements in the gastrocnemius muscle. Conclusions. The authors found that the results of regeneration after repair with longitudinal polyglactin sutures across short defects were not significantly different from those produced by the use of autologous nerve grafts. Regeneration, although poor, occurred along sutures across extended gaps and was significantly enhanced by an interposed nerve segment acting as a Schwann cell resource in this model.

Publishing year

2001

Language

English

Pages

316-323

Publication/Series

Journal of Neurosurgery

Volume

95

Issue

2

Document type

Journal article

Publisher

American Association of Neurosurgeons

Topic

  • Surgery

Keywords

  • nerve regeneration
  • absorbable suture
  • nerve graft
  • interposed nerve segment
  • Schwann cell
  • muscle force
  • nerve fiber

Status

Published

Research group

  • Hand Surgery, Malmö

ISBN/ISSN/Other

  • ISSN: 0022-3085