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Chromatin, epigenetics and stem cells

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Author

  • Tim C Roloff
  • Ulrike Nuber

Summary, in English

Epigenetics is a term that has changed its meaning with the increasing biological knowledge on developmental processes. However, its current application to stem cell biology is often imprecise and is conceptually problematic. This article addresses two different subjects, the definition of epigenetics and chromatin states of stem and differentiated cells. We describe mechanisms that regulate chromatin changes and provide an overview of chromatin states of stem and differentiated cells. Moreover, a modification of the current epigenetics definition is proposed that is not restricted by the heritability of gene expression throughout cell divisions and excludes translational gene expression control.

Department/s

Publishing year

2005

Language

English

Pages

123-135

Publication/Series

European Journal of Cell Biology

Volume

84

Issue

2-3

Document type

Journal article

Publisher

Elsevier

Topic

  • Cell and Molecular Biology

Keywords

  • Stem cells
  • Epigenetics
  • Chromatin
  • Histone modification
  • DNA methylation
  • Gene expression

Status

Published

ISBN/ISSN/Other

  • ISSN: 0171-9335