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Shaping up a lineage-lessons from B lymphopoesis.

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Author

Summary, in English

Even though the development of B lymphoid cells from hematopoietic stem cells is one of the most carefully investigated models of cell differentiation in adult mammalians, a set of recent findings has to a large extent increased our understanding for how B lymphoid commitment is achieved. These include the identification of IKAROS, PU.1 and E2A as transcription factors responsible for lymphoid lineage priming in multipotent cells, as well as the identification of EBF1 dependent B lineage restricted progenitors among cells lacking expression of the classical B lineage markers CD19 or B220. The insight that the B cell identity may be defined at an earlier stage then previously thought, allows for an increased understanding of B lymphoid development likely to unravel molecular mechanisms of high relevance also for other differentiation processes within as well as outside of the hematopoietic system.

Publishing year

2010

Language

English

Pages

148-153

Publication/Series

Current Opinion in Immunology

Volume

Apr 7

Document type

Journal article

Publisher

Elsevier

Topic

  • Immunology in the medical area
  • Cell and Molecular Biology

Status

Published

Research group

  • Immunology

ISBN/ISSN/Other

  • ISSN: 1879-0372