Long-term lead elimination from plasma and whole blood after poisoning.
Author
Summary, in English
OBJECTIVE:
Blood lead (B-Pb), one of the most used toxicological biomarker all kind, has serious limitations. Thus, the objective is to evaluate whether plasma lead (P-Pb) is more adequate.
METHODS:
A long-term follow-up study of five cases of lead poisoning. P-Pb was analysed by inductively coupled plasma mass spectrometry. Kinetics after end of exposure was modelled.
RESULTS:
P-Pb at severe poisoning was about 20 μg/L; haematological effects at about 5 μg/L. Biological half-time of P-Pb was about 1 month; B-Pb decay was much slower.
CONCLUSION:
P-Pb is a valuable biomarker of exposure to and risk, particularly at high exposure.
Blood lead (B-Pb), one of the most used toxicological biomarker all kind, has serious limitations. Thus, the objective is to evaluate whether plasma lead (P-Pb) is more adequate.
METHODS:
A long-term follow-up study of five cases of lead poisoning. P-Pb was analysed by inductively coupled plasma mass spectrometry. Kinetics after end of exposure was modelled.
RESULTS:
P-Pb at severe poisoning was about 20 μg/L; haematological effects at about 5 μg/L. Biological half-time of P-Pb was about 1 month; B-Pb decay was much slower.
CONCLUSION:
P-Pb is a valuable biomarker of exposure to and risk, particularly at high exposure.
Publishing year
2012
Language
English
Pages
311-316
Publication/Series
International Archives of Occupational and Environmental Health
Volume
85
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Document type
Journal article
Publisher
Springer
Topic
- Environmental Health and Occupational Health
Status
Published
ISBN/ISSN/Other
- ISSN: 1432-1246