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Anti-stress hormone may provide indication of breast cancer risk

Olle Melander and Mattias Belting
Olle Melander and Mattias Belting
A new study from Lund University in Sweden shows that women with low levels of an anti-stress hormone have an increased risk of getting breast cancer. The study is the first of its kind on humans and confirms previous similar observations from animal experiments.

The recent findings on a potential new marker for the risk of developing breast cancer are presented in the renowned Journal of Clinical Oncology. The study focused on a hormone which circulates freely in the blood, enkephalin, with pain- and anxiety-reducing properties. Enkephalin also reinforces the immune system by directly affecting immune cells.

“This is the first time the role of enkephalin in breast cancer has been studied in humans, and the results were surprisingly clear. Among women with the lowest levels of the hormone, the risk of breast cancer was more than three times that of the women with the highest levels of the hormone. This is one of the strongest correlations between cancer risk and a freely circulating biomarker ever described”, said Olle Melander and Mattias Belting, both professors at Lund University and consultant physicians at Skåne University Hospital.

The findings were possible thanks to a broad approach combining the latest knowledge within cancer and cardiovascular research at Lund University; the study was based on blood samples taken from just over 1 900 women in Malmö.  The women were followed up with regard to breast cancer for an average period of 15 years.

The results were adjusted for age, menopause, hormonal treatment, smoking and other factors which can affect the risk of getting breast cancer.

The current study confirms a statistical correlation between low enkephalin concentrations in the blood and increased risk of breast cancer, and it remains to be seen whether there is a causal relation showing that a low level of the hormone directly affects tumour development. The researchers also point out that geographical location and age, in spite of the adjustments in the study, may be significant. The average age of the women studied was 57.

On the other hand, the study’s results are backed up by a subsequent control study of a group of 1 500 women with a marginally higher average age. In this group, the link between low levels of the hormone and breast cancer was even stronger. Animal studies by other researchers also gave similar indications. These studies established that enkephalin can reinforce the activity of the immune system against cancer cells, as well as having a direct tumour-inhibiting effect.

The researchers at Lund University hope that, after further studies, the results will facilitate prevention and early detection of breast cancer.  For those with an increased risk of breast cancer, potential preventive treatments could take the form of lifestyle interventions to reduce stress and new drugs. The findings fit well with the development towards individualised risk assessment and treatment, on the basis of each woman’s needs.

“Our immediate plan is to investigate how to affect the level of enkephalin in healthy individuals. We will do this primarily in a study with a smaller number of women. We are also interested in the hormone’s role in other cancers”, said Olle Melander and Mattias Belting.

The study’s funders included the European Research Council (ERC), the Swedish Research Council and Region Skåne through ALF funds.

Publication: Stable Peptide of the Endogenous Opioid Enkephalin Precursor and Breast Cancer Risk


Olle Melander, professor of internal medicine at the Department of Clinical Sciences in Malmö, Lund University, and consultant physician at the internal medicine clinic, Skåne University Hospital
+46 70 454 68 20, +46 40 39 12 09
Olle [dot] Melander [at] med [dot] lu [dot] se

Mattias Belting, professor of oncology at the Department of Clinical Sciences in Lund, Lund University, and consultant physician at the oncology clinic at Skåne University Hospital
+46 73 350 74 73, + 46 46 17 85 49
Mattias [dot] Belting [at] med [dot] lu [dot] se

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