Nt-proANP in plasma, a marker of salt sensitivity, is reduced in type 2 diabetes patients.
Author
Summary, in English
Objective. We recently showed that plasma concentration of N-terminal atrial natriuretic peptide (Nt-proANP) is strongly directly related to salt sensitivity. The aims of the present study were to test (i) whether plasma concentration of N-terminal brain natriuretic peptide (Nt-proBNP) is related to salt sensitivity and (ii) whether Nt-proANP, as a marker of salt sensitivity, differs between type 2 diabetes patients and nondiabetic subjects without a history of coronary heart disease.
Methods. Nt-proBNP was determined in 30 Swedish normal subjects with heredity for primary hypertension and salt sensitivity was defined as the difference between mean arterial blood pressure after 1 week on a high-salt diet (240 mmol day-1) and 1 week on a low-salt diet (10 mmol day-1). Nt-proANP was measured in 253 patients with type 2 diabetes and in 230 nondiabetic subjects aged 40–70 years, all without a history of coronary heart disease.
Results. Amongst the 30 subjects, in whom salt sensitivity was directly measured, Nt-proBNP was not correlated with salt sensitivity (R = −0.18, P = 0.35). Nt-proANP (median, interquartile range) was lower in patients with type 2 diabetes (505, 387–661 pmol L-1) than in nondiabetic subjects (536, 421–696 pmol L-1) (P = 0.02). In a multiple regression analysis heart rate (P < 0.00001), diastolic blood pressure (P = 0.02) and diabetes status (P = 0.02) were inversely related whereas age (P < 0.00001), cystatin C (P = 0.0006), hypertension treatment (P = 0.002) and female sex (P = 0.006) were directly related to ln(Nt-proANP).
Conclusion. In contrast to Nt-proANP, Nt-proBNP is not related to salt sensitivity. Salt sensitivity, as estimated by Nt-proANP, seems to be reduced in type 2 diabetes.
Methods. Nt-proBNP was determined in 30 Swedish normal subjects with heredity for primary hypertension and salt sensitivity was defined as the difference between mean arterial blood pressure after 1 week on a high-salt diet (240 mmol day-1) and 1 week on a low-salt diet (10 mmol day-1). Nt-proANP was measured in 253 patients with type 2 diabetes and in 230 nondiabetic subjects aged 40–70 years, all without a history of coronary heart disease.
Results. Amongst the 30 subjects, in whom salt sensitivity was directly measured, Nt-proBNP was not correlated with salt sensitivity (R = −0.18, P = 0.35). Nt-proANP (median, interquartile range) was lower in patients with type 2 diabetes (505, 387–661 pmol L-1) than in nondiabetic subjects (536, 421–696 pmol L-1) (P = 0.02). In a multiple regression analysis heart rate (P < 0.00001), diastolic blood pressure (P = 0.02) and diabetes status (P = 0.02) were inversely related whereas age (P < 0.00001), cystatin C (P = 0.0006), hypertension treatment (P = 0.002) and female sex (P = 0.006) were directly related to ln(Nt-proANP).
Conclusion. In contrast to Nt-proANP, Nt-proBNP is not related to salt sensitivity. Salt sensitivity, as estimated by Nt-proANP, seems to be reduced in type 2 diabetes.
Department/s
Publishing year
2005
Language
English
Pages
281-288
Publication/Series
Journal of Internal Medicine
Volume
257
Issue
3
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Document type
Journal article
Publisher
Wiley-Blackwell
Topic
- Cardiac and Cardiovascular Systems
- Pharmacology and Toxicology
- Endocrinology and Diabetes
- Medicinal Chemistry
Status
Published
Research group
- Cardiovascular Research - Hypertension
- Genomics, Diabetes and Endocrinology
ISBN/ISSN/Other
- ISSN: 1365-2796