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Diabetes - Molecular Metabolism

Faculty of Medicine / Department of Clinical Sciences, Malmö
Website: http://www.med.lu.se/expmed/forskning/molekylaer_metabolism

Phone: +46 40 39 13 84

Fax number: +46 40 39 12 22

Visiting address: CRC, Hus 91 plan 11, Jan Waldenströms gata 35, Malmö

Diabetes - Molecular Metabolism's profile in Lund University Research portal

Description

The overall goal of our research unit is to understand metabolic control of insulin secretion and why it fails in type 2 diabetes (T2D). In recent years, this has meant that we have used information from GWAS (Genome-wide association study) to direct our efforts towards the genes which are actually linked to the development of the disease. To reach this overarching goal, we have worked along two lines: 1) mitochondrial (dys)function in β-cells and, 2) melatonin signaling in islets. In fact, these projects have emanated from findings in GWAS, where genetic variants of Transcription factor B1 mitochondrial (TFB1M) and the Melatonin receptor 1B have been robustly associated with T2D. Overall, our work holds promise to increase understanding of how T2D evolves. Mitochondrial function is difficult to target with drugs. In contrast, the melatonin receptor 1B is a potential drug target in T2D.

Coworkers

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  • Rodrigo Cataldo

    Postdoctoral fellow

    rodrigo [dot] cataldo [at] med [dot] lu [dot] se

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  • Sevda Gheibi

    Postdoctoral fellow

    sevda [dot] gheibi [at] med [dot] lu [dot] se

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J

K

  • Ida Kapusta

    Medical research assistant

    ida [dot] kapusta [at] med [dot] lu [dot] se

M

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  • David Nicholls

    Visiting research fellow

    david [dot] nicholls [at] med [dot] lu [dot] se

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  • Tania Singh

    Postdoc

    tania [dot] singh [at] med [dot] lu [dot] se

  • Jiangming Sun

    Assistant researcher

    jiangming [dot] sun [at] med [dot] lu [dot] se

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  • Gaurav Verma

    Postdoctoral fellow

    gaurav [dot] verma [at] med [dot] lu [dot] se