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Mitochondrial Medicine

Faculty of Medicine / Department of Clinical Sciences, Lund / Section IV / Clinical Neurophysiology

Phone: +46 46 222 06 05

Visiting address: BMC A13, Lund

Postal address: Sölvegatan 17, 221 84 Lund

Mitochondrial Medicine's profile in Lund University Research portal

Description

The energy-producing mitochondria are central to maintenance and survival of cells and have been proposed to participate in the pathogenesis of organ dysfunction. We use sensitive systems for analysis of mitochondrial function and have developed high-resolved respirometry applied to human blood cells. With this rapid and easy accessible method to monitor systemic mitochondrial function we determine bioenergetic capacity in children presenting with idiopathic encephalopathy or suspected mitochondrial disease, patients with chronic neurodegenerative disorders and patients with sepsis, conditions in which mitochondrial dysfunction has been implicated in the pathogenesis. An additional goal is to identify and move to clinical application pharmaceutical agents that can preserve or enhance mitochondrial function. For this purpose we have, in collaboration with industry, developed novel mitochondrial energy substrates and a porcine model of mitochondrial disease/acute metabolic decompensation.

Staff

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  • Magnus Hansson

    Research project participant

    magnus [dot] hansson [at] med [dot] lu [dot] se

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  • Märta Leffler

    Research project participant

    marta [dot] leffler [at] med [dot] lu [dot] se

  • Nora Li

    Research project participant

    nora [dot] li [at] med [dot] lu [dot] se

  • Tianshi Liu

    Research project participant

    tianshi [dot] liu [at] med [dot] lu [dot] se

  • Karolina Löwgren

    Research project participant

    karolina [dot] lowgren [at] med [dot] lu [dot] se

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  • Sigurdur Marelsson

    Research project participant

    sigurdur [dot] marelsson [at] med [dot] lu [dot] se

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  • Shusuke Sekine

    Research project participant

    shusuke [dot] sekine [at] med [dot] lu [dot] se

  • Fredrik Sjövall

    Research project participant

    fredrik [dot] sjovall [at] med [dot] lu [dot] se

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  • Emil Westerlund

    Research project participant

    emil [dot] westerlund [at] med [dot] lu [dot] se

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