Menu

Javascript is not activated in your browser. This website needs javascript activated to work properly.
You are here

Link between appendicitis and allergies discovered

Children with allergies have a lower risk of developing complicated appendicitis, according to a new study from Lund University and Skåne University Hospital in Sweden. The findings, now published in JAMA Pediatrics, could pave the way for new diagnostic tools in the future.
Martin Salö
Martin Salö

“In a study of all the children who underwent surgery for appendicitis in Lund, Sweden, over the span of a decade, we found that the most common form of allergy, such as allergy to pollen and animal fur, was associated with a three times lower risk of developing complicated appendicitis. The lower risk remained when we adjusted for other parameters known to increase the risk of serious appendicitis, such as lower age and long-lasting symptoms”, says Martin Salö, a researcher at Lund University and physician at Skåne University Hospital.

Appendicitis is widespread among children and young people, and the condition is the most common cause of emergency abdominal surgery in the world.

One third of children affected have a more complicated form of appendicitis which requires a longer hospital stay and sometimes several surgeries. It is not yet clear why some children are affected by this more serious form of appendicitis, nor whether it is possible to prevent it.

One theory holds that complicated appendicitis depends on the body’s immunological response differing to the response in cases of uncomplicated appendicitis. According to this theory, children with allergies have a lower risk of contracting complicated appendicitis, because their immunological response is different from that of non-allergic children. However, this had not been investigated more closely until now.

“The outcome of the study supports the theory that complicated appendicitis has a different immunological development compared to uncomplicated appendicitis. The results also provide clues that we hope can lead to the development of new diagnostic aids such as blood tests”, concludes Martin Salö.

The study in brief:

The study included all children under the age of 15 who underwent surgery for appendicitis at Skåne University Hospital in Lund between 2007 and 2017. In total, 605 children were part of the study. The researchers compared the outcomes for children with what is known as IgE-mediated allergy (102 children) with those for children without this allergy (503 children). Among the children with IgE-mediated allergy, 19.6% contracted more complicated appendicitis. In the group of children with no IgE-mediated allergy, 46.9% were affected. 

Link to publication: Association of IgE-Mediated Allergy With Risk of Complicated Appendicitis in a Pediatric Population

Contact:
Martin Salö, Researcher at Lund University and specialist physician at Skåne University Hospital, Department of Pediatric Surgery
+46 46-178372
martin [dot] salo [at] med [dot] lu [dot] se

 

Categories

Latest news

13 November 2019

How self-reactive immune cells are allowed to develop

How self-reactive immune cells are allowed to develop
12 November 2019

Iron-based solar cells on track to becoming more efficient

Iron-based solar cells on track to becoming more efficient
11 November 2019

WATCH: Unique technology will make gesture control more accurate

WATCH: Unique technology will make gesture control more accurate
7 November 2019

Lund researchers have tracked a black hole near red giant star

Lund researchers have tracked a black hole near red giant star
31 October 2019

Key mechanism in insulin release by cholesterol metabolite found

Key mechanism in insulin release by cholesterol metabolite found