Diabetes - Epigenetics

Faculty of Medicine / Department of Clinical Sciences, Malmö
Website: http://www.ludc.med.lu.se/research-units/diabetes-and-endocrinology/

Phone: +46 40 39 12 13

Visiting address: CRC, Hus 91 plan 11, Jan Waldenströms gata 35, Malmö

Diabetes - Epigenetics' profile in Lund University Research portal

Description

Type 2 diabetes develops as a conspiracy between the genetic background and the environment. The interaction between genes and environment may involve epigenetic factors, such as DNA methylation and histone modifications, to promote type 2 diabetes. The overall objective of our research is to identify the key epigenetic mechanisms influencing the pathogenesis of T2D. We are currently analysing DNA methylation and histone modifications in a number of human cohorts. Here, we examine if non-genetic and genetic factors as well as type 2 diabetes affect epigenetic variation in human tissues. We are further relating DNA methylation to gene expression, in vivo metabolism and type 2 diabetes. Furthermore, we are dissecting the role of epigenetic enzymes in development of type 2 diabetes.

Coworkers

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  • Line Hjort

    Postdoctoral fellow

    line [dot] hjort [dot] 1517 [at] med [dot] lu [dot] se

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  • Charlotte Ling

    Professor, Research team manager

    charlotte [dot] ling [at] med [dot] lu [dot] se

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  • Beatrice Yang

    Research student

    beatrice [dot] yang [at] med [dot] lu [dot] se

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