Sukrit Singh

Why did you choose Lund University?

I chose Lund University because presents the best of what interdisciplinary science can promise! Being able to do clinically relevant research using physics with national computing infrastructure (alongside facilities like MAX IV) opens new possibilities that are rarely available all in one geographic location.

Can you briefly describe your current research?

My work combines physics-based simulation, AI/ML models, and high-throughput experiment to understand how clinically occurring mutations alter drug resistance, selectivity, and sensitivity. 

In doing so, my work predicts the mechanisms by which mutations drive drug resistance, and informs which treatments may no longer be effective in the presence of specific mutations.

What will be your main research focus during your time at Lund University?

My lab will establish physics/AI-based precision medicine; We combine quantitative models, biophysics, and experimentation to study when clinically-occurring mutations resist therapies or drive disease through overactivation/loss-of-function. We will identify when these variants are sensitized to rarely-used inhibitors, opening up therapeutic strategies in personalized medicine.