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Experimental Epilepsy Group

Faculty of Medicine / Department of Clinical Sciences, Lund / Section IV / Epilepsy Center

Visiting address: Wallenberg Neuroscience Center, BMC A11, Sölveg 17, 221 84 Lund

Postal address: Sölvegatan 17, BMC A11, 221 84 Lund

Experimental Epilepsy Group's profile in Lund University Research portal

Description

Epilepsy is one of the most devastating neurological diseases, affecting at least 60 million people worldwide. But despite certain progress in antiepileptic drug developmental, available pharmacological treatments are only symptomatic, have side effects and fail to adequately control seizures in a third of patients. Recently, neuropeptides and neurotrophic factors emerged as strong regulators of synaptic transmission in the CNS, offering a potent tool to counteract the seizure activity. However, it is not clear yet what the role of these agents is in mechanisms of epileptogenesis. We do research to develop gene therapy strategies based on neuropeptides and neurotrophic factors. We also use optogenetics and chemogenetics as tools to investigate mechanisms of epileptogenesis with the aim to develop these techniques as possible therapeutic approach to suppress seizures.

Staff

J

  • Susanne Jonsson

    Research project participant

    susanne [dot] jonsson [at] med [dot] lu [dot] se

K

  • Merab Kokaia

    Project manager

    merab [dot] kokaia [at] med [dot] lu [dot] se

L

  • Marco Ledri

    Research project participant

    marco [dot] ledri [at] med [dot] lu [dot] se

M

  • Esbjörn Melin

    Research project participant

    esbjorn [dot] melin [at] med [dot] lu [dot] se