Chemistry: Advanced Biochemistry
Course · 15 credits
Dive into the world of membrane proteins - learn about their role in the cell's energy metabolism, cell signaling and communication and as targets for pharmaceutical drugs
KEMM23. Membrane proteins are absolutely necessary for the energy metabolism of the cell and for its ability to sense and communicate with its envrionment. About half of all pharmaceutical drugs used today target membrane bound proteins. In this course you will learn more about different types of membrane proteins, how they can be overexpressed and purificed from a host cell and how different methods can be used to analyse their structure and function. The course includes predictions and practical investigations of protein folding in a membrane, as well as a shorter project where you under guidance plan and carry out cloning and overexpression of a membrane protein of your choice.
Lectures: The lectures address the three different main types of membrane proteins and associated cellular processes: transport and transporters, signal transduction and receptors, bioenergetics and photosynthetic and respiratory proteins. A number of proteins from each process, for which the structure is known, are explored in greater detail in order to highlight the functional molecular mechanisms. Lectures dealing with methods for theoretical modelling of membrane protein structure, fusion protein techniques, X-ray crystallography, heterologous expression, solubilisation and purification of membrane proteins are also included in the course.
Laboratory sessions, exercises and project work: Determination of the transmembrane topology of a protein starts with a model of the protein bases on sequence information and theoretical methods. This is followed by experimental determination using genetic construction and expression of a fusion protein of the membrane protein and a marker protein in a bacterial system which is subsequently analysed.
In silicon exercise addressing potential problems concerning the detection of heterologously expressed membrane proteins, solubilisation and evaluation of detergent properties, ion exchange chromatography and gel filtering in the presence of a detergent, and control of the protein's stability and integrity after purification.
An individually planned and executed minor project during two weeks, in which the students express a membrane protein of their choice and demonstrate in some way that the expression was successful. The project entails practice in literature searching, project planning and documentation, and provides specialised practical knowledge of expression and management of membran proteins. The project is to be concluded with a poster presentation.
Closed for applicationsApplication opportunities
Undergraduate Studies in Chemistry
Naturvetarvägen 14 / Sölvegatan 39 A, 223 62 Lund
Box 124, 221 00 Lund
+46 46 222 83 40
sophie [dot] manner [at] chem [dot] lu [dot] se
+46 46 222 83 57
lovisa [dot] andersson [at] kilu [dot] lu [dot] se
Requirements and selection
90 ECTS credits Science studies including KEMA20, or KEMA10 and KEMA12, KEMA01, KEMA03 and MOBA02. English 6/English Course 6.
Seats are allocated according to: Previous college/university studies (APAV): 100 %.
English language requirements
Most of Lund University’s programmes require English Level 6 (unless otherwise stated under 'Entry requirements'). This is the equivalent of an overall IELTS score of 6.5 or a TOEFL score of 90. There are several ways to prove your English language proficiency – check which proof is accepted at the University Admissions in Sweden website. All students must prove they meet English language requirements by the deadline, in order to be considered for admission.
How to apply
Lund University uses a national application system run by University Admissions in Sweden. It is only possible to apply during the application periods.
Step 1: Apply online
- Check that you meet the entry requirements of the programme or course you are interested in (refer to the section above on this webpage).
- Start your application – go to www.universityadmissions.se where you create an account and select programmes/courses, during the application period.
- Rank your programme/course choices in order of preference and submit them before the application deadline.
Step 2: Submit documents
- Read about how to document your eligibility and how to submit your documents at www.universityadmissions.se. Follow any country-specific document rules for Master's studies or Bachelor's studies.
- Get all your documents ready: official transcripts and high school diploma (Bachelor's applicants), official transcripts and degree certificate or proof of expected graduation (Master's applicants), passport/ID and proof of English proficiency (all applicants).
- Prepare programme-specific documents if stated in the adjacent column on this webpage.
- Upload or send all required documents to University Admissions before the document deadline.
- Pay the application fee (if applicable – refer to the section below on this webpage) before the document deadline.
*Note that the process is different if you are applying as an exchange student or as a part of a cooperation programme (such as Erasmus +).
*If you have studied your entire Bachelor's programme in Sweden and all of your academic credits are in Ladok, you do not have to submit transcripts or your diploma when applying for a Master's programme. However, there may still be other documents you need to submit! See the link below.
*Svensk student? Läs instruktionerna om att söka till ett internationellt masterprogram på lu.se
Full programme/course tuition fee: SEK 36 250
First payment: SEK 36 250
Citizens of a country outside of the European Union (EU), the European Economic Area (EEA) and Switzerland are required to pay tuition fees. You pay one instalment of the tuition fee in advance of each semester.
EU/EEA citizens and Switzerland
There are no tuition fees for citizens of the European Union (EU), the European Economic Area (EEA) and Switzerland.
If you are required to pay tuition fees, you are generally also required to pay an application fee of SEK 900 (approximately EUR 100) when you apply at www.universityadmissions.se. You pay one application fee regardless of how many programmes or courses you apply to.
Read more about paying the University Admissions in Sweden application fee and exemptions on the University Admissions website.
*Note that there are no tuition or application fees for exchange students or PhD students, regardless of their nationality.
Scholarships & funding
Lund University Global Scholarship programme
The Lund University Global Scholarship programme is a merit-based and selective scholarship targeted at top academic students from countries outside the EU/EEA.
Swedish Institute Scholarships
The Swedish Institute offers scholarships to international students applying for studies in Sweden at Bachelor's, Master's, PhD and post-doctoral levels.
Country-specific scholarships and funding options
Lund University has agreements with scholarship organisations and funding bodies in different countries, which may allow applicants to apply for funding or scholarships in their home countries for their studies at Lund University.
- Scholarships/funding for students from Brazil, Indonesia, Mexico, Colombia, Russia and Chile
- US student finance
- Canada student finance