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Minor components with smooth muscle relaxing properties from scented myrrh (Commiphora guidotti)

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Author

Summary, in English

All sesquiterpenes present in a sample of scented myrrh were isolated and characterised. Seven compounds, with cadinane, guaiane, oplopane, and eudesmane skeletons, were obtained, of which two are new and two are reported from a natural source for the first time. The major component, T-cadinol, has previously been shown to possess smooth muscle-relaxing properties, and the major purpose of the investigation was to compare the effects of the minor and more polar sesquiterpenes with that of T-cadinol in the rat aorta. Like T-cadinol, the minor sesquiterpenes are more efficient in reducing K(+)-induced contractions than those induced by the alpha-adrenoceptor agonist phenylephrine, however, they were all less potent than T-cadinol.

Publishing year

1997

Language

English

Pages

251-254

Publication/Series

Planta Medica

Volume

63

Issue

3

Document type

Journal article

Publisher

Georg Thieme Verlag

Topic

  • Medicinal Chemistry
  • Dermatology and Venereal Diseases
  • Pharmacology and Toxicology

Keywords

  • Scented myrrh
  • Commiphora guidotti
  • Burseraceae
  • sesquiterpenes
  • T-cadinol
  • smooth muscle relaxant

Status

Published

ISBN/ISSN/Other

  • ISSN: 0032-0943